流变学在热熔挤出制剂的研究进展

刘永娇, 伊珊, 陆杨, 熊素彬

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (5) : 345-351.

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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (5) : 345-351. DOI: 10.11669/cpj.2019.05.001
综述

流变学在热熔挤出制剂的研究进展

  • 刘永娇, 伊珊, 陆杨, 熊素彬*
作者信息 +

Research Progress on Rheology in the Holt Melt Extrusion

  • LIU Yong-jiao, YI Shan, LU Yang, XIONG Su-bin*
Author information +
文章历史 +

摘要

热熔挤出(HME)是一种新型的固体分散和熔融制粒制剂技术。药物和高分子在HME过程受热、剪切和拉伸等作用呈现复杂的流变特性,流变学是指导热熔挤出制剂处方、工艺和过程控制的理论基础。笔者综述了熔体流变特性与温度和剪切速率的关系,以及时-温等效等流变学基本原理;常用流变仪及其在研究药用高分子熔体的热塑性,药物在高分子熔体的溶解性,药物与高分子相互作用,热熔挤出工艺参数的筛选及过程分析(PAT)等方面的进展。

Abstract

Hot melt extrusion (HME) is a novel technique to prepare solid dispersions and granules. During the manufacturing process, the drugs and polymers melt and show the complex rheological properties under the heat and forces of shear and extension. Rheology is a potential tool to guide their formulations, manufacturing process and in-line quality control. In this review, we summarized the basic theories of the molten polymer viscoelasticity with temperature and shear rate, and the time-temperature superposition, the widely used rheometries and their applications in the pharmaceutical polymer thermoplasticity, drug solubility and interactions in the molten polymers, manufacturing parameters and the in-line quality control of hot melt extrusion.

关键词

流变学 / 高分子 / 热熔挤出 / 热塑成型 / 固体分散

Key words

rheology / polymer / hot melt extrusion / thermoplastic molding / solid dispersion

引用本文

导出引用
刘永娇, 伊珊, 陆杨, 熊素彬. 流变学在热熔挤出制剂的研究进展[J]. 中国药学杂志, 2019, 54(5): 345-351 https://doi.org/10.11669/cpj.2019.05.001
LIU Yong-jiao, YI Shan, LU Yang, XIONG Su-bin. Research Progress on Rheology in the Holt Melt Extrusion[J]. Chinese Pharmaceutical Journal, 2019, 54(5): 345-351 https://doi.org/10.11669/cpj.2019.05.001
中图分类号: R944   

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基金

国家自然科学基金项目资助(30701059);浙江省自然科学基金项目资助(LY13H300004)
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